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Diverse Population Studies: Trials should include diverse patient populations, especially including individuals at risk for obesity-associated comorbidities, to ensure generalizability and to assess efficacy and safety across different subgroups

A 52-week treatment with tirzepatide (5mg, 10mg, or 15 mg) led to a significant MASH resolution without worsening liver fibrosis compared to placebo (Fig.3)

It was found through preliminary research that treatment with AOD9604 over the course of 14 days in obese mice led to decreased body weight and body fat and was shown to increase the activity of the beta(3)-adrenergic receptors in the fat cells to the same level as those in lean mice

However, the efficacy of GLP-1R agonists to reduce drinking in this subgroup may diverge from those without surgery, as GLP-1 is increased after surgery ( In conclusion, these preclinical and clinical studies point toward the possibility of using GLP-1R agonists to treat patients with addictions, an interaction that should be elucidated in future studies